Posttranslational Modifications and Their Control in CHO Culture
The Chinese hamster ovary (CHO) cell line was first established by Theodore Puck in the 1950s and was used mainly for cytogenetics studies (1). Since the 1990s, CHO cells have increased in popularity...
View ArticleMind the Gap: Managing Relationships Between Upstream and Downstream...
Process intensification (PI) describes an integrated framework of strategies to maximize the output of a unit operation, a process, or an entire facility. By implementing PI strategies,...
View ArticleScaling AAV Production: Easing the Transition from Laboratory Scales to...
Adenoassociated virus (AAV) has emerged as the leading vector for gene therapy delivery. Compared with options such as lentivirus and adenovirus, AAV exhibits a strong safety profile because it has low...
View ArticleNavigating New Options for Commercial-Scale Biopharmaceutical Production
Scalability remains a critically important topic for biopharmaceutical companies. For conventional protein products, the strategy once was straightforward: Drug makers would scale up, beginning with...
View ArticleTransfection: Past, Present, and Future
The science behind transfection spans from calcium phosphate precipitation to newer methods that are easier to perform, more efficient, and consistent. Mirus Bio strives to perfect gene delivery to...
View ArticleHardware, Software, and Wetware: 20 Years of Advancements in...
The past couple of decades have witnessed significant advances in upstream bioprocess technologies and approaches. Since its establishment, BPI has been a facilitator of discussion in both print and...
View ArticleEnabling Next-Generation Biomanufacturing Using Cell-Free Technology
Weston Kightlinger, director, cell-free protein synthesis, National Resilience. Kightlinger shared his company’s work to enable next-generation biomanufacturing, focusing on biologics and cell-free...
View ArticleDeciphering Nutritional Needs in Bioprocess Optimization: Targeted and...
Microbiology has risen as a major part of global industry over the past three decades. Industrial microbiology, biotechnology, biopharma and now biointelligent production systems (1) embrace a wide...
View ArticleA Case Study in Environmental Monitoring: Reviewing Incubation Times Upon...
Environmental monitoring (EM) remains an essential detection tool for cleanrooms within healthcare and pharmaceutical-manufacturing facilities. During monitoring, an agar growth medium is incubated at...
View ArticleStandard Operating Procedures in a Good Practice Environment: Benefit or Burden?
I was both excited and curious the day I started a new job in the quality affairs department of a pharmaceutical company. As usual, I attended onboarding meetings and received a training plan that...
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